WHAT IT IS
Two peptides. Two mechanisms. One outcome: the body stops breaking and starts fixing.
BPC-157 — Body Protection Compound — is a 15-amino-acid fragment of a protein your stomach produces to keep itself from dissolving. Researchers pulled out the sequence that does the protecting. It acts locally: angiogenesis at the wound site, growth-hormone receptor upregulation on tendon cells, cytokine suppression, collagen synthesis.
TB-500 is a synthetic 7-amino-acid fragment corresponding to the active region (residues 17–23, acetylated) of native Thymosin Beta-4 (Tβ4, 43 amino acids). TB-500 ≠ TB-4. TB-500 is the piece of TB-4 that does the regenerative work, isolated and shelf-stable. It acts systemically: mobilizes progenitor cells from reservoir tissue to damaged tissue, upregulates actin, reduces inflammation across muscle, tendon, cardiac, and neural systems.
MECHANISM
BPC-157 · LOCAL
- — Angiogenesis at the wound site
- — GH receptor upregulation on tendon fibroblasts
- — NO (nitric oxide) pathway modulation
- — Cytokine suppression (breaks the inflammation loop)
- — Collagen synthesis
- — Gastric-stable → oral liposomal viable for gut pathology
TB-500 · SYSTEMIC
- — Actin upregulation (cell scaffolding)
- — Stem/progenitor cell mobilization to injury
- — Angiogenesis (stacks with BPC-157)
- — Anti-inflammatory across multiple tissue types
- — Keeps repair cells alive long enough to finish the job
DOSING
The math people actually need at the kitchen counter. Units on a U-100 insulin syringe, not lit-review microgram ranges.
RECONSTITUTION · WATCH
Mixing the vial the first time is the moment most people screw up. Watch before you draw.
Mixing the vial the first time is the moment most people screw up. Watch once before you draw. No research-paper microgram arithmetic — U-100 insulin syringe units, standard bacteriostatic water.
- › Swirl, don't shake. Proteins fracture under shear.
- › Reconstitute once — store the mixed vial refrigerated, use within 30 days.
- › SubQ rotation: abdomen, flank, outer thigh. Alcohol prep. Sharps bin.
ROUTES
Default. Highest bioavailability. Orthopedic + systemic dosing. Inject near the injury when anatomically reasonable.
BPC-157 only. Gastric-stable. Preferred for GI pathology: ulcers, leaky gut, IBS, post-surgical gut.
Limited evidence. Not primary. Adjunctive for surface wounds or local skin healing in combination with SubQ.
CYCLE + TIMELINE
Inflammation drops. Sleep often improves. Pain starts to disengage.
Tissue remodeling. The injury stops dominating your day.
Structural repair. What was a problem usually isn't anymore.
CONTRAINDICATIONS
- ⚠ ACTIVE MALIGNANCY — angiogenesis is pro-tumor in oncology contexts. Hard stop until you're clear.
- ⚠ PREGNANCY / LACTATION — insufficient safety data.
- ⚠ HYPERSENSITIVITY — known allergy to any component.
- ⚠ ANTICOAGULATION — discuss with your physician first.
STACKS WITH
Each link opens its protocol page. Stack logic explained at the target.
COMMUNITY DATA
Self-reported outcomes from 412 registered participants. Polls anonymous. Data contributes to IRB PPRN-001-2025.
SATISFACTION
n=412WHEN DID YOU SEE RESULTS?
n=378SIDE EFFECT SEVERITY
n=412WOULD YOU RECOMMEND?
n=398ADVERSE EVENTS
Structured reports filed by protocol participants. All submissions flow into the IRB PPRN-001-2025 registry. If you experienced anything out of the ordinary on this protocol — even mild — please report it. That's the data that makes research real.
Takes 2–3 minutes. Anonymous OK. Your report helps the next person stay safe.
DISCUSSION
Patient-to-patient. Not medical advice. Not moderated by clinicians in real time. Flag posts that violate the ToS.
Achilles tendinopathy, 14 months refractory to PT + PRP. Started Wolverine 10u M-F, bumped to 20u at week 3. Week 4 I ran a 5k pain-free for the first time since 2024. Still finishing the cycle but wanted to share while I'm in it.
ACL reconstruction Feb. Surgeon gave me the usual 6-month timeline. Started Wolverine 3 weeks post-op with his OK. At 8 weeks I'm cleared for partial load, which is basically 4 weeks ahead of schedule. n=1, but.
Anyone else notice the combo vial from Supplier X reconstitutes cloudy? Switched to Supplier Y and it went clear. Same bac water. Curious if it's a filler/mannitol issue or a quality thing.
GET IT
peptide.buzz
Oral liposomal BPC-157 + TB-500 combo. Ships direct. Our preferred retail partner.
BUY AT peptide.buzz →peptidepure.com
Research-grade injectable for prescribers with NPI + state license. Gated for a reason.
ORDER AT peptidepure →BUYING 50+ UNITS?
Gym, coaching practice, clinic, reseller? Case-pack pricing + ACH / net-30 available.
This is research. Not medicine. Not advice. Do not hold us responsible for what you do with information you sought out voluntarily. Work with a licensed physician before starting any peptide. This protocol and the data captured on this page are registered under IRB PPRN-001-2025 (practice-based research network). Registry contributions are voluntary and anonymous by default.